Adverse effects

AKI

• dose response associated between statin and AKI

  • >70% taking simvastatin

• within 1 yr of initiation

• remained for first 5 years

• return to N wihin 1-3 years

• wiht CVRA ≥ 15% NNT = 44F and 38M

• NNH for AKI = 593F, 447M

• benefit and harms increase for cvra ≥20%